How Peripheral Neuropathy Is Treated with Hyperbaric Oxygen Therapy Patients suffering from peripheral neuropathy experience various symptoms, often starting with numbness in the extremities and progressing to severe, potentially life-threatening symptoms. Treatments have historically included anti-seizure medications, antidepressants, and pain medications with a high probability of addiction, such as oxycodone. However, recent studies have shown that hyperbaric oxygen therapy may provide non-addictive relief for patients suffering from peripheral neuropathy. To understand the benefits of hyperbaric oxygen therapy, we must first recognize what peripheral neuropathy is and how the disease affects its victims.